Marek Michalak

Distinguished University Professor
Ph.D., Nencki Institute
M.Sc. University of Warsaw
Department of Biochemistry
Faculty of Medicine & Dentistry
University of Alberta
355 Medical Sciences Building
Edmonton, Alberta, Canada  T6G 2H7
Tel: 780.492.2256
Lab Tel: 780.492.3481
Fax:  780.492.0886

Our lab studies the structure and function of endoplasmic reticulum (ER) membranes and the role of this membrane system in the control of intracellular signalling, communication with other intracellular organelles, regulation of protein synthesis and folding, modulation of gene expression and calcium homeostasis. We discovered that ER resident chaperones play critical roles in cardiac development and pathophysiology of the mature heart. The proteins are also key in specific neuropathies. Our long-term goal is to  devise pharmacological and genetic therapies for the treatment of human disease.

Here are a few examples of research projects currently being pursued in our lab:

Modulators of ER stress
We are pursuing a variety of strategies to use this information to manipulate ER stress pathways and to uncover additional regulators of ER stress.

Calreticulin, ER resident proteins and cardiac physiology.
We are investigating the contribution of calreticulin, ER stress coping responses to cardiac pathology including heart failure.

ER calcium homeostasis and energy metabolism
We are interested in understanding the role of ER luminal environment in regulation of ER-dependent Ca2+ signaling and regulation of energy metabolism and its role in human pathology.

Deciphering a role of ER chaperones in neuropathies
We are interested in understanding the role of calnexin and ER stress in the pathology of the nervous system with a special emphasis on human neuropathies such as Multiple Sclerosis, amyotrophic lateral sclerosis (ALS) and myelin diseases.

Lab Members:

Jody Groenendyk, Research Associate
Joanna Jung, Postdoctoral Fellow

Alison Robinson, Technologist
Hector Vega, Graduate Student
Wen-An (Jennifer) Wang, Graduate Student
Qian Wang, Graduate Student
Selected Publications:

Groenendyk, J., Lee, D., Jung, J., Dyck, J.R.B., Lopaschuk, G.L., Agellon, L.B. and Michalak, M. 2016. Inhibition of the unfolded protein response mechanism prevents cardiac fibrosis. PLoS ONE 11: e0159682​

Groenendyk, J., Peng, Z., Dudek, E., Fan, X., Mizianty, M.J., Dufey, E., Urra, H., Sepulveda, D., Rojas-Rivera, D., Yunki, L., Kim, D.H., Baretta, K., Srikanth, S., Gwack, G., Ahnn, J., Kaufman, R.J., Lee, S-K., Hetz, C., Kurgan, L. and Michalak M. 2014. Interplay between PDIA6 and miR-322 controls adaptive response to disrupted endoplasmic reticulum calcium homeostasis. Science Signaling(329): ra54
Lee, D., Oka, T., Hunter, B., Robinson, A., Papp, S., Nakamura, K., Srisakuldee, W., Nicke, B.E., Light, P.E., Dyck, J.R.B., Lopaschuk, G.L., Kardami, E., Opas, M. and Michalak, M. 2013. Calreticulin induces dilated cardiomyopathy. PLoS ONE,8:e56387
Groenendyk, J., Agellon, L.B. and Michalak, M. 2013. Coping with endoplasmic reticulum stress in the cardiovascular system. Annu. Rev. Physiol75: 49-67
Millott, R., Dudek, E. and Michalak, M. 2012. The endoplasmic reticulum in cardiovascular health and disease. Can. J. Physiol. Pharmacol90: 1209-1217
Li H-D, Liu W-X and Michalak M. 2011. Enhanced clathrin-dependent endocytosis in the absence of calnexin. PLoS ONE 6:e21678
Groenendyk J and Michalak M. 2011. A Genome-wide siRNA screen identifies novel phospho-enzymes affecting Wnt/?-catenin signaling in mouse embryonic stem cells. Stem Cell Rev. Rep. 7:910-926
Jung J, Coe H and Michalak M. 2011. Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22.FASEB J. 25:3929-3937
Prins D, Groenendyk J, Touret N and Michalak M. 2011. Endoplasmic reticulum luminal environment-dependent regulation of STIM1 and capacitative Ca2+ entry. EMBO Rep. 12:1182-1188