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John S. Colter Lectureship
William A. Bridger Lectureships in Biochemistry
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Ing Swie Goping
Our Disease Focused Research
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Our Disease Focused Research
Distinguished University Professor
Ph.D., Nencki Institute
M.Sc. University of Warsaw
Department of Biochemistry
Faculty of Medicine & Dentistry
University of Alberta
355 Medical Sciences Building
Edmonton, Alberta, Canada
Lab Tel: 780.492.3481
Our lab studies the structure and function of endoplasmic reticulum (ER) membranes and the role of this membrane system in the control of intracellular signalling, communication with other intracellular organelles, regulation
Our lab studies the structure and function of endoplasmic reticulum (ER) membranes and the role of this membrane system in the control of intracellular signalling, communication with other intracellular organelles, regulation of protein synthesis and folding, modulation of gene expression and calcium homeostasis.
We discovered that ER resident chaperones play critical roles in cardiac development and pathophysiology of the mature heart. The proteins are also key in specific neuropathies. Our long-term goal is to understand ER stress and ER signaling events responsible for the activation and maintenance of intracellular pathways affecting cardiac or neuronal physiology and pathology, and to use this information to devise pharmacological and genetic therapies for the treatment of human disease.
Here are a few examples of research projects currently being pursued in our lab:
Modulators of ER stress
We have identified several cellular proteins that regulate ER stress responses and the unfolded protein response (UPR), including ER luminal resident chaperones and folding enzymes. We are pursuing a variety of strategies to use this information to manipulate ER stress pathways and to uncover additional regulators of ER stress.
Calreticulin, ER resident proteins and cardiac physiology.
We apply gene knockout and transgenic techniques to understand the role of ER proteins and the ER luminal environment in embryogenesis and congenital pathologies. We are investigating the contribution of calreticulin and other ER resident proteins to cardiac pathology including cardiac hypertrophy and heart failure.
ER calcium homeostasis
is an important second messenger. Ca
is released from the ER into the cytoplasm and the loss of ER Ca
stores necessitates refilling
a process known as store-operated Ca
entry (SOCE). We are interested in understanding the role of ER luminal environment in regulation of ER-dependent Ca
signaling and its role in human pathology.
ER chaperones and energy metabolism
Disrupted ER homeostasis due to loss of ER chaperones may lead to dysregulation of energy metabolism. We are interested in the mechanisms responsible for ER-dependent modulation of energy metabolism with a special emphasis on the role of ER associated molecular chaperones.
Deciphering a role of ER chaperones in neuropathies
We discovered that calnexin-deficient mice develop a
specific neuropathy, dysmyelination and impaired motor function
. We are interested in understanding the role of calnexin and ER stress in the pathology of the nervous system with a special emphasis on human neuropathies such as Multiple Sclerosis, amyotrophic lateral sclerosis (ALS) and myelin diseases.
Elzbieta Dudek, Postdoctoral Fellow
Jody Groenendyk, Research Associate
Joanna Jung, Postdoctoral Fellow
Alison Robinson, Technical
Hector Vega, Graduate Student
Wen-An (Jennifer) Wang, Graduate Student
Qian Wang, Graduate Student
Groenendyk, J., Peng, Z., Dudek, E., Fan, X., Mizianty, M.J., Dufey, E., Urra, H., Sepulveda, D., Rojas-Rivera, D., Yunki, L., Kim, D.H., Baretta, K., Srikanth, S., Gwack, G., Ahnn, J., Kaufman, R.J., Lee, S-K., Hetz, C., Kurgan, L. and
2014. Interplay between PDIA6 and miR-322 controls adaptive response to disrupted endoplasmic reticulum calcium homeostasis.
Lee, D., Oka, T., Hunter, B., Robinson, A., Papp, S., Nakamura, K., Srisakuldee, W., Nicke, B.E., Light, P.E., Dyck, J.R.B., Lopaschuk, G.L., Kardami, E., Opas, M. and
. 2013. Calreticulin induces dilated cardiomyopathy.
Groenendyk, J., Agellon, L.B. and
. 2013. Coping with endoplasmic reticulum stress in the cardiovascular system.
Annu. Rev. Physiol
Millott, R., Dudek, E. and
. 2012. The endoplasmic reticulum in cardiovascular health and disease.
Can. J. Physiol. Pharmacol
Li H-D, Liu W-X and
. 2011. Enhanced clathrin-dependent endocytosis in the absence of calnexin.
Groenendyk J and
2011. A Genome-wide siRNA screen identifies novel phospho-enzymes affecting Wnt/?-catenin signaling in mouse embryonic stem cells.
Stem Cell Rev. Rep.
Jung J, Coe H and
2011. Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22.
Prins D, Groenendyk J, Touret N and
2011. Endoplasmic reticulum luminal environment-dependent regulation of STIM1 and capacitative Ca2+ entry.
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