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Michael Ellison

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Professor
Ph.D. University of Toronto
 
Department of Biochemistry
Faculty of Medicine & Dentistry
University of Alberta
4-020G Katz Group – Rexall Centre for Pharmacy and Health Research
Edmonton, Alberta, Canada  T6G 2E1
 
Phone: 780-492-6352
Lab Phone: 780-492-5839
Fax:  780-492-0886
 
 
Research:
 
At the beginning of his career Mike Ellison’s interests were primarily centred on the structure and function of complex biomolecules. More recently his interests have tended towards the possibility of constructing synthetic biological devices that perform useful functions.
 
He received his Ph.D. from the University of Toronto in 1983 for research focused on chromosome structure. He spent the next six years at MIT developing accurate computational approaches for predicting the physical behaviour of bio-macromolecules. There, his interests shifted toward understanding the ubiquitin system, an important cellular signaling pathway that formed the core of his research program at the University of Alberta from 1990 to 2003.
 
His current focus is on Synthetic Biology, an emerging discipline that sits at the interface between biology and engineering. The goal of this new field is to produce modular biological circuits of increasing sophistication using well-understood molecular components that can be reliably assembled into novel and useful forms of artificial life. As Synthetic Biology theme leader of the Bioconversions network, his current efforts are directed toward the creation of microbial systems with the capacity to produce high value chemical feed stocks from provincially available sources of biomass.
 
He continues to be a strong advocate for innovative science. He has served on the boards of Genome Prairie, the Alberta Network for Proteomic Innovation and has played a major role in bringing new technologies to the university through two multi-million dollar investments from the Canada Foundation for Innovation. He is actively engaged in the dissemination of synthetic biology to undergraduates with his involvement in iGEM, a student research competition held annually at MIT.
 
 
Lab Members
Nien-tsu Tseng
 
Selected Publications:
 

Ridgway D, Broderick G, Ellison MJ. (2006) Accommodating space, time and randomness in network simulation. Curr Opin Biotechnol 17: 493-8.
 
Broderick G, Ru'aini M, Chan E, Ellison MJ. (2005) A life-like virtual cell membrane using discrete automata In Silico. Biol 5: 163-78.
 
Lopez-Campistrous A, Semchuk P, Burke L, Palmer-Stone T, Brokx SJ, Broderick G, Bottorff D, Bolch S, Weiner JH, Ellison MJ. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol Cell Proteomics 4:1205-9.
 
Moraes TF, Edwards RA, McKenna S, Pastushok L, Xiao W, Glover JN, Ellison MJ. (2001) Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. Nat Struct Biol 8:669-73.