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Joe Casey

 

JCasey.jpg
 
Ph.D., University of Toronto
Professor​

 
Department of Biochemistry
Faculty of Medicine & Dentistry
University of Alberta
4020E Katz Group Rexall
Edmonton, Alberta, Canada  T6G 2E1

Tel:  780-492-7203
Lab Tel:  780-492-1080
Fax:  780-492-0886


joe.casey@ualberta.ca

Casey Website


Research:

The laboratory’s passion is membrane transport. How do integral membrane transport proteins function as micro-machines to move substances selectively across our cell’s membranes? How does disease arise when these processes go wrong?
Bicarbonate Transport proteins move bicarbonate (HCO3-) across the plasma membrane of our cells.  This process is essential to control cell levels of the waste product carbon dioxide (CO2) and to regulate the pH (acid level) both inside and outside our cells.  Bicarbonate transport is a simple yet central part of our body's normal functioning.  Disruption of bicarbonate transport underlies many diseases. Our laboratory studies the role of bicarbonate transport in causing disease.  Supported by two operating grants from the Canadian Institutes of Health Research, our major projects ongoing in our laboratory include:
1.  Determining the structure and transport mechanism of the chloride/bicarbonate exchanger, AE1, which is central to red  blood cell and kidney function. 
2.  How do defects in the transport protein called SLC4A11 cause blinding corneal diseases: Fuch's endothelial dystrophy and congenital hereditary endothelial dystrophy?
 

Lab Members:

Kumari Alka, Postdoctoral Fellow
Nada Alshumaimeri, Graduate Student
Katherine Badior, Graduate Student
Mike Chiu, Graduate Student 
Chris Lukowski, Research Technician
Darpan Malhotra, Graduate Student
Sam Post, Lab Assistance

 
Selected Publications:

Loganathan, S.K.
, and Casey, J.R. (2014) Corneal Dystrophy-causing SLC4A11 Mutants: Suitability for Folding-Correction Therapy, Human Mutation, 35, 1082-91. (Article selected for a video highlight; See http://www.youtube.com/watch?v=rLvUicNtsoM)

 
Sowah, D., Brown, B.F., Quon, A., Alvarez, B.V., and Casey, J.R. (2014) Resistance to Cardiomyocyte Hypertrophy in ae3-/- Mice, Deficient in the AE3 Cl-/HCO3- Exchanger, BMC Cardiovascular Disorders, 14:89.
 
Alka, K. and Casey J.R. (2014) Bicarbonate Transport in health and disease, IUBMB Life, In Press.
 
Vilas, G.L., Loganathan, S., Liu J., Riau, A.K., Young, J.D., Mehta, J.S., Vithana, E.N. and Casey, J.R. (2013) Transmembrane water flux through SLC4A11: a route defective in corneal diseases, Human Mol. Genet., 22, 4579-90.
 
Bonar, P.T., Schneider, H.P., Becker, H.M., Deitmer, J.W., and Casey, J.R. (2013) Three-Dimensional Model for the Human Cl-/HCO3- Exchanger, AE1, by Homology to the E. coli ClC Protein J. Mol. Biol. 425, 2591-2608.
 
Alvarez, B.V., Quon, A., Mullen, J. and Casey, J.R. (2013) Quantification of carbonic anhydrase gene expression in ventricle of hypertrophic and failing human heart, BMC- Cardiovascular Disorders, 13:2.
 
Vilas, G.L., Loganathan, S., Quon, A.,, Sundaresan, P., Vithana, E.N and Casey, J.R. (2012) Oligomerization of SLC4A11 protein and the severity of FECD and CHED2 corneal dystrophies caused by SLC4A11 mutations, Human Mutation, 33, 419-428.
 
Johnson, D.E. and Casey, J.R. (2011) Cytosolic H+ Microdomain Developed Around AE1 During AE1-Mediated Cl-/HCO3- Exchange, J. Physiol., 589, 1551-69.
 
Vilas, G.L., Morgan, P.E., Loganathan, S., Quon, A., and Casey, J.R. (2011) Biochemical Framework for SLC4A11, the Plasma Membrane Protein Defective in Corneal Dystrophies Biochemistry, 50, 2157-69.
 
Casey, J.R., Orlowski, J. and Grinstein, S. (2010) Sensors and Regulators of the Intracellular pH Nature Reviews Molecular Cell Biology, 11, 50-61.
 
Vithana, E.N, Morgan, P.E., Ramprasad, V., Tan, D.T.H., Yong, V.H.K., Venkataraman, D., Venkatraman, A., Yam, G.H.F., Nagasamy, S., Law, R.W.K., Rajagopal, R., Pang, C.P., Kumaramanickevel, G., Casey, J.R, Aung, T. (2008) SLC4A11 Mutations in Fuchs Endothelial Corneal Dystrophy (FECD) Hum.  Mol. Genet., 17, 656-666.
 
Vithana, E.N. Morgan, P.E., Sundaresan, P., Ebenezer, N., Tan, D.T.H., Anand, S., Khine, K.O., Venkataraman, D., Yong, V., Salto-Tellez, M., Venkataraman, A., Guo, K., Hemadevi, B., Mohamed, M.D., Srinivasan, M., Prajna, V., Khine, M., Casey, J.R., Inglehearn, C.F., & Aung, T. (2006) Mutations in Na+-borate co-transporter SLC4A11 cause recessive Congenital Hereditary Endothelial Dystrophy CHED2 Nature Genetics, 38, 755-7.