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Nicolas Touret

 

Touret70.jpg

Associate Professor
Ph.D, Molecular and Cellular Biology
University of Nice-Sophia Antipolis
France, 2001

Department of Biochemistry
Faculty of Medicine & Dentistry
University of Alberta
4-020H Katz Group – Rexall Centre for Pharmacy and Health Research
Edmonton, Alberta, Canada  T6G 2E1 

 

Tel: 780.492.3513
Lab Tel: 780.492.0209
Fax:  780.492.0886

touret@ualberta.ca
Lab Website

Research:

The laboratory is focused on elucidating the molecular mechanisms involved in the initiation of immune responses when the organism is challenged with pathogens.
 
We are using new imaging technologies, capable of resolving the behavior of single molecules, to define the change of state overtime that receptors of innate immune cells (macrophages and dendritic cells) are undergoing during their interaction with pathogen’s molecules.

Lab Members:
Swai Mon Khaing, Graduate Student
Sandra Ungarian, Technical

Publications:
Wang H, Wei E, Quiroga AD, Sun X, Touret N, Lehner R. Altered Lipid Droplet Dynamics in Hepatocytes Lacking Triacylglycerol Hydrolase Expression. Mol Biol Cell. 2010 Jun 15; 21(12):1991-2000.
 
Koivusalo M, Welch C, Hayashi H, Scott CC, Kim M, Alexander T, Touret N, Hahn KM, Grinstein S. Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol. 2010 Feb 22; 188(4):547-63.
 
Steinberg BE, Touret N, Vargas-Caballero M, Grinstein S. In situ measurement of the electrical potential across the phagosomal membrane using FRET and its contribution to the proton-motive force. PNAS. 2007 May 29;104(22):9523-8.
 
Martin-Orozco N*, Touret N*, Zaharik ML, Park E, Kopelman R, Miller S, Finlay BB, Gros P, Grinstein S. Visualization of Vacuolar Acidification-induced Transcription of Genes of Pathogens inside Macrophages. Mol Biol Cell. 2006 Jan;17(1):498-510.
 
Touret N*, Paroutis P*, Terebiznik M, Harrison R, Trombetta S, Pypaert M, Chow A, Jiang A, Shaw J, Yip C, Moore HP, van der Wel N, Houben D, J. Peters PJ, de Chastellier C, Mellman I and Grinstein S. Quantitative and dynamic assessment of the contribution of the endoplasmic reticulum to phagosome formation. Cell. 2005 Oct 7;123(1):157-70.