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Courses

BIOCH 510
Signal Transduction - second term
Principles of the biochemistry of cell communication and signal transduction through receptor activation, the generation of second messengers, and the control of protein modifications. The course will emphasize the mechanisms responsible for the regulation of cell migration, division and death. Prerequisites: BIOCH 310, 320 and 330, or BIOCH 203 and 205, all with a minimum grade of B-, or consent of the Department.
Notes:
(1) Lectures are the same as for BIOCH 410, but with additional assignments and evaluation appropriate to graduate studies.
(2) This course may not be taken for credit if credit has already been obtained in BIOCH 410.
 
BIOCH 520
Protein
Chemistry, Structure, and Function  - first term
Protein chemistry and purification. The intra- and intermolecular forces that determine protein structure. Principles of protein folding and dynamics. Enzyme mechanisms and ligand binding interactions.
Prerequisites: BIOCH 320, or BIOCH 203 and 205, all with a minimum grade of B- or consent of Department.
Notes:
(1) Lectures are the same as for BIOCH 420, but with additional assignments and evaluation appropriate to graduate studies.
(2) This course may not be taken for credit if credit has already been obtained in BIOCH 420.
 
BIOCH 530
Bi
ochemistry of Eukaryotic Gene Expression - first term
The organization and expression at the molecular level of information encoded in the nucleic acids of eukaryotic cells. The focus will be on genome structure and the regulation of gene expression at the levels of transcription, post-transcriptional processing, translation, post-translational modification and protein sorting. Recombinant DNA technologies and genetic engineering will be discussed as methods for studying the cellular processing of genetic information.
Prerequisites: BIOCH 320 and 330, or BIOCH 203 and 205, all with a minimum grade of B- or consent of Department.
Notes:
(1) Lectures are the same as for BIOCH 430, but with additional assignments and evaluation appropriate to graduate studies.
(2) This course may not be taken for credit if credit has already been obtained in BIOCH 430.
 
BIOCH 541
S
tructure and Function of Biological Membranes - first term
Survey of the structure and function of biological membranes. Topics include the structure, properties and composition of biomembranes, characterization and structural principles of membrane lipids and proteins, lateral and transverse asymmetry, dynamics, lipid-protein interactions, membrane enzymology, permeability, and biogenesis.
Prerequisites: BIOCH 320, or BIOCH 203 and 205, all with a minimum grade of B- or consent of Department.
Notes:
(1) Lectures are the same as for BIOCH 441, but with additional assignments and evaluation appropriate to graduate studies.
(2) This course may not be taken for credit if credit has already been obtained in BIOCH 441.
 
BIOCH 550
The Molecular Biology of Mammalian Viruses -  first term
This course will focus on virus structure, replication, and interaction with host cells at the molecular level. Lytic viruses with single- or double-stranded DNA or RNA genomes will be discussed, as will the mechanisms of viral oncogenesis.
Prerequisites: BIOCH 320 and 330, or BIOCH 203 and 205, all with a minimum grade of B- or consent of Department.
Notes:
(1) Lectures are the same as for BIOCH 450, but with additional assignments and evaluation appropriate to graduate studies.
(2) This course may not be taken for credit if credit has already been obtained in BIOCH 450.
 
BIOCH 555
Biochemistry of Lipids and Lipoproteins - second term
Advanced course focusing on specific aspects of the regulation of lipid and lipoprotein metabolism. Topics include the transcriptional and post-translational mechanisms governing the synthesis and degradation of important enzymes, lipids, and lipid transport molecules; the role of lipid mediators in signaling pathways and protein modification; the assembly and dynamics of lipoproteins and biological membranes; genetic disruptions of lipid regulatory proteins such as cell surface receptors leading to human disease.
Prerequisites: BIOCH 310, 320, and 330, or BIOCH 203 and 205, all with a minimum grade of B- or consent of Department.
Notes:
(1) Lectures are the same as for BIOCH 455, but with additional assignments and evaluation appropriate to graduate studies.
(2) This course may not be taken for credit if credit has already been obtained in BIOCH 455.

BIOCH 560
Physical Biochemistry - first term
Survey of physical techniques used in the characterization and structural determination of biological macromolecules. Topics include hydrodynamics, optical and magnetic resonance spectroscopies, diffraction techniques such as X-ray crystallography, and small angle neutron and X-ray scattering. Emphasis is on using techniques in evaluating structure-function relationships by a discussion of representative macromolecular systems.
Prerequisites: BIOCH 320, or BIOCH 203 and 205, all with a minimum grade of B- or consent of Department. Prerequisites or corequisites: CHEM 371 and 373, or consent of Department.
Notes:
(1) Lectures are the same as for BIOCH 460, but with additional assignments and evaluation appropriate to graduate studies.
(2) This course may not be taken for credit if credit has already been obtained in BIOCH 460.​

BIOCH 565
Methods in Molecular Biophysics - second term
Survey of biophysical methods used in the characterization and structural determination of biological macromolecules, from ensemble measurements to single-molecule detection. Topics include mass spectrometry, optical spectroscopy, light microscopy, X-ray and neutron diffraction, electron microscopy, molecular dynamics and nuclear magnetic resonance. Emphasis is on using techniques in evaluating structure-function relationships through the discussion of representative macromolecular systems.
Prerequisites: BIOCH 320 with a minimum grade of B- or consent of the Department. This course cannot be taken for credit if credit has already been obtained in BIOCH 460.
 
BIOCH 609
Macromolecular Structure Analysis - second term
             
Principles of X-ray crystallography as applied to the study of protein and nucleic acid structure. Practical aspects of diffraction and structure solution are demonstrated by a collaborative study of a suitable small molecule of biological interest. Designed for senior honors and graduate students.
Prerequisite: consent of Instructor.
Notes:
(1) Maximum enrolment of 10 students. Offered in alternate years.
 
BIOCH 620
Selected Topics in Protein Structure, Function, and Regulation
second term
Directed reading and seminar course, based on papers taken from recent literature of protein research. Students critically discuss the papers and give oral presentations to the class. Designed for graduate students.
Prerequisite: BIOCH 420 or equivalent, or consent of Department.
 
BIOCH 623A
Special Topics in Research on Polynucleotides - two term                    
This course is a journal club and discussion group in which current research topics on nucleic acids are discussed. Specific talks range from biochemistry, genetics and microbiology to nuclear biology and clinical aspects.
 
BIOCH 623B
S
pecial Topics in Research on Polynucleotides  - two term                     
This course is a journal club and discussion group in which current research topics on nucleic acids are discussed. Specific talks range from biochemistry, genetics and microbiology to nuclear biology and clinical aspects.
 
BIOCH 626A
Special Topics in Protein Research - two term
Seminar course for advanced students. Detailed consideration is given to recent advances in research on protein structure and function and mechanism of enzyme action.
Prerequisite: BIOCH 420 or consent of Department.
 
BIOCH 626B
Special Topics in Protein Researchpecial Topics in Protein Research - two term
Seminar course for advanced students. Detailed consideration is given to recent advances in research on protein structure and function and mechanism of enzyme action.
Prerequisite: BIOCH 420 or consent of Department.
 
BIOCH 630
Selected Topics in Modern Molecular Biology - second term
Directed reading and seminar course, based on papers taken from the recent literature of molecular biology. Students critically discuss the papers and give oral presentations. 
Prerequisite: BIOCH 530 and consent of the Department.
Note: designed for graduate students; offered yearly.
 
BIOCH 640A
Special Topics in Research on Biomembranes - two term
Seminar course for advanced students covering selected topics from the current literature in the field of membrane structure and function.
Prerequisite: BIOCH 441 or consent of Department.
 
BIOCH 640B
Special Topics in Research on Biomembranes - two term
Seminar course for advanced students covering selected topics from the current literature in the field of membrane structure and function.
Prerequisite: BIOCH 441 or consent of Department.
 
BIOCH 641
Selected Topics on the Structure and Function of Biological Membranes -
first term         
Directed reading and seminar course on the structure and function of biological membranes. Topics include membrane biogenesis, bioenergetics, transport and structural aspects of membrane lipids and proteins.
Prerequisite: BIOCH 441 or consent of the Department.
 
BIOCH 650A
Signal Transduction -  two term       
A journal club and discussion group addressing topics in the general area of signalling mechanisms that control cell activation, growth, apoptosis and vesicle trafficking. Specific talks range from biochemistry, genetics and microbiology to molecular biology and clinical aspects.
Prerequisite: BIOCH 410/510 or consent of Department.
 
BIOCH 650B
Signal Transduction - two term
A journal club and discussion group addressing topics in the general area of signalling mechanisms that control cell activation, growth, apoptosis and vesicle trafficking. Specific talks range from biochemistry, genetics and microbiology to molecular biology and clinical aspects.
Prerequisite: BIOCH 410/510 or consent of Department.
 
BIOCH 651A
Special Topics in Lipid and Lipoprotein Research - two term
Seminar for advanced students covering selected topics from the current literature in the field of lipid and lipoprotein research.
Prerequisite: BIOCH 555 or consent of Department.
 
BIOCH 651B
Special Topics in Lipid and Lipoprotein Research -  two term
Seminar for advanced students covering selected topics from the current literature in the field of lipid and lipoprotein research.
Prerequisite: BIOCH 555 or consent of Department.
 
BIOCH 655
Advances in Lipid and Lipoprotein Research - first term        
Recent developments and use of the current literature are emphasized. Topics include regulation of lipid metabolism, intracellular lipid trafficking, regulation of lipoprotein secretion, lipid transfer among lipoproteins, reverse cholesterol transport, and atherosclerosis.
Prerequisite: BIOCH 455, or 555, or consent of Department. 
Note: Offered in alternate years.
 
BIOCH 670A
Recent Advances in Biochemistry - two term 
A seminar course on topics of current interest in biochemistry. Students will contribute to a presentation based on recent developments published in first rate journals. Attendance at all seminars is expected.
Note: Open only to graduate students in Biochemistry.
 
BIOCH 670B
Recent Advances in Biochemistry - two term  
A seminar course on topics of current interest in biochemistry. Students will contribute to a presentation based on recent developments published in first rate journals. Attendance at all seminars is expected.
Note: Open only to graduate students in Biochemistry.
 
BIOCH 671A 
Recent Advances in Biochemistry - two term  
A seminar course on topics of current interest in biochemistry. Students will contribute a presentation on their research project that includes original data. Attendance at all seminars is expected. Prerequisite: BIOCH 670 or consent of the Department.
Note: Open only to graduate students in Biochemistry.
 
BIOCH 671B
Recent Advances in Biochemistry -  two term
A seminar course on topics of current interest in biochemistry. Students will contribute a presentation on their research project that includes original data. Attendance at all seminars is expected.
Prerequisite: BIOCH 670 or consent of the Department.
Note: Open only to graduate students in Biochemistry.
 
BIOCH 675
Magnetic Resonance in Biology and Medicine II  - second term
Designed for advanced honors and graduate students interested in the application of nuclear magnetic resonance spectroscopy to biological systems. Topics include quantum mechanical basis of NMR, multinuclear multidimensional NMR experiments, NMR relaxation theory, new NMR applications. 
Prerequisite: consent of Instructor.
Note: Offered in alternate years.